Research in Dr. Aizenman’s laboratory is directed towards investigating cellular signaling processes leading to neuronal cell death and devising novel approaches to neuroprotection. Acute and chronic injurious processes in the brain lead to the activation of signaling cascades that eventually result in the demise of neurons. In Dr. Aizenman’s laboratory, cellular pathways leading to cell death are molecularly dissected in order to provide novel therapeutic targets to treat neurodegenerative disorders. This laboratory works on potential common final mediators of cell death signaling events that can be effectively targeted to treat neural disorders. This work is primarily focused on acute neuronal injury, such as stroke, although the results obtained from these studies could have broader applications to more chronic neurodegenerative conditions. Over the last several years, the laboratory has investigated redox and photic regulation of NMDA receptors, excitotoxicity, dopamine oxidation pathways, zinc-mediated neurotoxicity, zinc signaling and epilepsy, and Kv2.1 potassium channel facilitated forms of neuronal apoptosis.
The laboratory uses a wide range of techniques that include cellular electrophysiology, molecular biology, protein biochemistry, cell culture, cell imaging, gene-expression assays, toxicity assays, pharmacological screening and, in collaboration with Dr. Dandan Sun, in vivo ischemia models.
|PhD||Toxicology||Johns Hopkins University||1985|
|Post-doctoral||Neuroscience||Harvard Medical School||1985-1987|
|Instructor||Harvard Medical School||1987-1989|
|Assistant Professor||Harvard Medical School||1989|
|Assistant Professor||University of Pittsburgh||1989-1994|
|Associate Professor||University of Pittsburgh||1994-2001|
|Professor||University of Pittsburgh||2001-|
|Adjunct Professor||Ben Gurion University||2010-|
Honors and awards
Summa Cum Laude with Distinction, Boston University (1981)
Phi Beta Kappa (1981)
Alumni Award in Biology, Boston University (1981)
NRSA in Developmental Neurology, Children’s Hospital and Harvard Medical School (1985-1987)
Research Fellowship, Fight for Sight (1985-1987)
BRRT Study Section, NIH (1994-1998)
Independent Investigator Award, NARSAD (1997)
Dozor Visiting Scholar, Ben Gurion University (2006)
President, International Society for Zinc Biology (2011-2013)
NOMD Study Section, NIH (2012-2018; Chair: 2017-2018)
William E. Brown Outstanding MSTP Mentor Award (2015)
Dozor Visiting Scholar, Ben Gurion University (2017)
Yeh, C.-Y., A.M. Bulas, A. Moutal, J.L. Saloman, K.A. Hartnett, C.T. Anderson, T. Tzounopoulos, D. Sun, R. Khanna and E. Aizenman. Targeting a potassium channel/syntaxin interaction ameliorates cell death in ischemic stroke. Journal of Neuroscience 2017; 37:5648-5658.
Justice, J.A., A.J. Schulien, K. He, K.A. Hartnett, E. Aizenman and N.H. Shah. Disruption of Kv2.1 somato-dendritic clusters prevents the apoptogenic increase of potassium currents. Neuroscience 2017; 354:158-167.
Schulien, A.J., J.A. Justice, R. Di Maio, Z.P. Wills, N.H. Shah and E. Aizenman. Zinc-induced calcium release via ryanodine receptors triggers calcineurin-dependent redistribution of cortical neuronal Kv2.1 K+ channels. Journal of Physiology 2016; 594:2647-2659.
He, K., M.C. MCord, K.A. Hartnett and E. Aizenman. Regulation of pro-apoptotic phosphorylation of Kv2.1 K+ channels. PLoS One 2015; 10(6):e0129498.
McCord, M.C., P.H. Kullmann, K. He, K.A. Hartnett, J.P. Horn, I. Lotan and E. Aizenman. Syntaxin-binding domain of Kv2.1 is essential for the expression of apoptotic K+ currents. Journal of Physiology 2014; 592:3511-3521.
Shah, N.H., A.J. Schulien, K. Clemens, T.D. Aizenman, T.M. Hageman, Z.P. Wills and E. Aizenman. Cyclin E1 regulates Kv2.1 channel phospohorylation and localization in neuronal ischemia. Journal of Neuroscience 2014; 34:4326-4331.
McCord, M.C. and E. Aizenman. Convergent calcium and zinc signaling regulates apoptotic Kv2.1 potassium currents. Proceedings of the National Academy of Sciences (USA) 2013; 110:13988-13993.
Norris, C.A., K. He, M.G. Springer, K.A. Hartnett, J.P. Horn and E. Aizenman. Regulation of neuronal pro-apoptotic potassium currents by the hepatitis C virus non-structural protein 5A. Journal of Neuroscience 2012; 32:8865-70.
Jason Justice, PhD