Bradley Molyneaux, MD, PhD
Assistant Professor of Neurology and Critical Care MedicineE-mail
Dr. Molyneaux’s laboratory is investigating mechanisms of injury and repair of the cerebral cortex. By purifying individual subtypes of projection neurons from the developing neocortex and sequencing their transcriptomes, he has identified transcription factors that play critical roles in cortical projection neuron development, discovered novel noncoding RNA's that are unique to individual subtypes of neurons, and gained new insight into the complexity of the cortical transcriptome. He is applying similar methods to identify new mechanisms of neuroprotection and plasticity after injury.
Dr. Molyneaux is the site principal investigator for several multicenter clinical trials, including GAMES-RP, which is testing whether glyburide can ameliorate malignant edema after large ischemic strokes, and ATACH-II, which is testing whether early, intensive antihypertensive treatment is beneficial in intracerebral hemorrhage. As a member of UPMC’s Post Cardiac Arrest Service, he is engaged in collaborative research focused on optimizing the management of patients after cardiac arrest for neuroprotection.
|AB||Molecular Biology||Dartmouth College||1998|
|Internship||Medicine||Massachusetts General Hospital||2008|
|Residency||Neurology||Partners Neurology, Harvard University||2011|
|Fellowship||Neurocritical Care||Partners Neurology, Harvard University||2013|
|Fellowship||Stem Cell and Regenerative Biology||Harvard University||2013|
|Assistant Professor||University of Pittsburgh||2013-present|
Molyneaux, B.J.*, Goff, L.A.*, Brettler, A.C., Chen, H.H., Hrvatin, S., Rinn, J.L., and Arlotta, P. 2015. DeCoN: genome-wide analysis of in vivo transcriptional dynamics during pyramidal neuron fate selection in neocortex. Neuron. 85:275-288. Highlighted in video abstract. (please make the words “video abstract” link to this page - https://www.youtube.com/watch?v=S1xHO4zfUA0)
Aghaebrahim, A., Jadhav, A.P., Saeed, Y, Totoraitis, R., Jankowitz, B.T., Jovin, T., and Molyneaux, B.J. (2014). Reversible cerebral vasoconstriction syndrome following carotid stenting. Neurology. 83:570-571.
Lodato, S., Molyneaux, B.J., Zuccaro, E., Goff, L.A., Chen, H.H., Yuan, W., Meleski, A., Takahashi, E., Mahony, S., Rinn, J.L., Gifford, D.K., and Arlotta, P. (2014). Gene co-regulation by Fezf2 selects neurotransmitter identity and connectivity of corticospinal neurons. Nature Neuroscience. 17:1046-1054.
Molyneaux, B.J.*, Arlotta, P.*, MacQuarrie, K., and Macklis, J.D. (2009) Novel Subtype-specific Genes Identify Distinct Subpopulations of Callosal Projection Neurons. Journal of Neuroscience. 29:12343-54. (with cover)
Joshi, P.S., Molyneaux, B.J., Feng, L., Xie, X., Macklis, J.D., and Gan, L. (2008) Bhlhb5 regulates the postmitotic acquisition of area identities in layers II-V of the developing neocortex. Neuron. 60:258-72.
Arlotta, P.*, Molyneaux, B.J.*, Jabaudon, D., Yoshida, Y., and Macklis, J.D. (2008) Ctip2 controls the differentiation of medium spiny neurons and the establishment of the cellular architecture of the striatum. Journal of Neuroscience. 28:622-632.
Molyneaux, B.J.*, Arlotta, P.*, Menezes, J., and Macklis, J.D. (2007) Neuronal Subtype Specification in the Cerebral Cortex. Nature Reviews Neuroscience. 8:427-437.
Molyneaux, B.J.*, Arlotta, P.*, Hirata, T., Hibi, M., and Macklis, J.D. (2005) Fezl Is Required for the Birth and Specification of Corticospinal Motor Neurons. Neuron. 47: 817-831. (*equal contributions)