Molyneaux Laboratory

Bradley Molyneaux, MD, PhD

Assistant Professor of Neurology and Critical Care Medicine
E-mail

Interests

Dr. Molyneaux’s laboratory is investigating mechanisms of injury and repair of the cerebral cortex. By purifying individual subtypes of projection neurons from the developing neocortex and sequencing their transcriptomes, he has identified transcription factors that play critical roles in cortical projection neuron development, discovered novel noncoding RNA's that are unique to individual subtypes of neurons, and gained new insight into the complexity of the cortical transcriptome. He is applying similar methods to identify new mechanisms of neuroprotection and plasticity after injury.

Dr. Molyneaux is the site principal investigator for several multicenter clinical trials, including GAMES-RP, which is testing whether glyburide can ameliorate malignant edema after large ischemic strokes, and ATACH-II, which is testing whether early, intensive antihypertensive treatment is beneficial in intracerebral hemorrhage. As a member of UPMC’s Post Cardiac Arrest Service, he is engaged in collaborative research focused on optimizing the management of patients after cardiac arrest for neuroprotection.

Training

AB Molecular Biology Dartmouth College 1998
PhD Neurobiology Harvard University 2006
MD Medicine Harvard University 2007
Internship Medicine Massachusetts General Hospital 2008
Residency Neurology Partners Neurology, Harvard University 2011
Fellowship Neurocritical Care Partners Neurology, Harvard University 2013
Fellowship Stem Cell and Regenerative Biology Harvard University 2013

Positions Held

Assistant Professor University of Pittsburgh 2013-present

Selected Publications

Molyneaux, B.J.*, Goff, L.A.*, Brettler, A.C., Chen, H.H., Hrvatin, S., Rinn, J.L., and Arlotta, P. 2015. DeCoN: genome-wide analysis of in vivo transcriptional dynamics during pyramidal neuron fate selection in neocortex. Neuron. 85:275-288. Highlighted in video abstract. (please make the words “video abstract” link to this page - https://www.youtube.com/watch?v=S1xHO4zfUA0)

Aghaebrahim, A., Jadhav, A.P., Saeed, Y, Totoraitis, R., Jankowitz, B.T., Jovin, T., and Molyneaux, B.J. (2014). Reversible cerebral vasoconstriction syndrome following carotid stenting. Neurology. 83:570-571.

Lodato, S., Molyneaux, B.J., Zuccaro, E., Goff, L.A., Chen, H.H., Yuan, W., Meleski, A., Takahashi, E., Mahony, S., Rinn, J.L., Gifford, D.K., and Arlotta, P. (2014). Gene co-regulation by Fezf2 selects neurotransmitter identity and connectivity of corticospinal neurons. Nature Neuroscience. 17:1046-1054.

Molyneaux, B.J.*, Arlotta, P.*, MacQuarrie, K., and Macklis, J.D. (2009) Novel Subtype-specific Genes Identify Distinct Subpopulations of Callosal Projection Neurons. Journal of Neuroscience. 29:12343-54. (with cover)

Joshi, P.S., Molyneaux, B.J., Feng, L., Xie, X., Macklis, J.D., and Gan, L. (2008) Bhlhb5 regulates the postmitotic acquisition of area identities in layers II-V of the developing neocortex. Neuron. 60:258-72.

Arlotta, P.*, Molyneaux, B.J.*, Jabaudon, D., Yoshida, Y., and Macklis, J.D. (2008) Ctip2 controls the differentiation of medium spiny neurons and the establishment of the cellular architecture of the striatum. Journal of Neuroscience. 28:622-632.

Molyneaux, B.J.*, Arlotta, P.*, Menezes, J., and Macklis, J.D. (2007) Neuronal Subtype Specification in the Cerebral Cortex. Nature Reviews Neuroscience. 8:427-437.

Molyneaux, B.J.*, Arlotta, P.*, Hirata, T., Hibi, M., and Macklis, J.D. (2005) Fezl Is Required for the Birth and Specification of Corticospinal Motor Neurons. Neuron. 47: 817-831. (*equal contributions)

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